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The N-receptor complicated undergoes a structural change that permits its translocation to the mobile nucleus, where by it instantly binds to certain nucleotide sequences with the chromosomal DNA. The generated DNA interferes While using the physiological biosynthesis of testosterone.
Apoptosis has actually been claimed to Engage in a vital position from the regulation of germ mobile populations in the adult testes. The correlation between apoptosis and substantial AAS doses and exercise routines has a short while ago been experimentally assessed in animal styles. Shokri et al. report a big rise in the speed of apoptosis of spermatogenic cells following nandrolone administration, a rise clearly amplified by physical training [five].
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